Early Data Show Cancer Progression Associated With Increased Risk of Death in Patients With COVID-19

Treatment with combination of hydroxychloroquine and azithromycin also strongly associated with greater risk of death
For immediate release
May 28, 2020

*Scroll down to view the press briefing presentation*

ASCO Perspective
“The cancer care community urgently needs data on the effects of COVID-19, specifically in patients with cancer. How  we improve the care we provide these patients and reduce the number of deaths and severe consequences associated with this disease are among the top questions. The COVID-19 and Cancer Consortium registry is a great example of the community quickly coming together to identify and collect the data we need on a large scale,” said ASCO President Howard A. Burris III, MD, FACP, FASCO. 

ALEXANDRIA, Va. — In patients with cancer and COVID-19, cancer that is progressing was independently associated with an increased risk of death, according to an analysis of 928 patients. COVID-19 treatment with both hydroxychloroquine and azithromycin was also strongly associated with increased risk of death, according to data from the COVID-19 and Cancer Consortium (CCC19) registry. The registry contains data from patients who have tested positive for COVID-19 and around 40% of patients in the registry also have active cancer. The data will be presented as part of the virtual scientific program of the 2020 American Society of Clinical Oncology (ASCO) Annual Meeting. 

Study at a Glance

Focus 30-day all-cause mortality 
Population 525 patients with cancer diagnosed with COVID-19 
Findings Cancer progression and treatment with hydroxychloroquine and azithromycin were associated with a 5.2-fold and 2.89-fold greater risk of death at 30 days compared with patients in remission/no evidence of disease 
Significance The findings could lead to better understanding of the relationship between cancer and COVID-19 to improve care for these patients 

“This is early and evolving data, and more time and analysis will be needed to confirm and expand on these findings,” said lead author Jeremy L. Warner, MD,  Associate Professor of Medicine and Biomedical Informatics at Vanderbilt University Medical Center in Nashville. “Right now, we’re working to quickly get information about why some patients with cancer become infected with the SARS-CoV-2 virus and identify the factors that affect disease severity and death. We're also interested in the effects of treatments that are being used to treat patients with cancer who have COVID-19.”  

Key Findings 
Thirteen percent of patients (121) died within 30 days of COVID-19 diagnosis. After partial adjustment for several baseline factors, patients with progressing cancer were found to be 5.2 times more likely to die within 30 days compared with patients in remission or with no evidence of disease.  

Use of a combination of hydroxychloroquine and azithromycin to treat COVID-19 was associated with a 2.89-fold greater risk of 30-day mortality than use of neither drug. However, there was no significant increase in risk associated with the use of either drug alone. Patients who received hydroxychloroquine and azithromycin and later died were more likely to have had slightly diminished daily physical function, received cancer therapy less than 2 weeks before COVID-19 diagnosis, have Rh-positive blood type, be of non-Hispanic ethnicity, and use statins at baseline.  

“While these findings are provocative, we believe that there is significant confounding by indication and that carefully planned prospective studies are needed to truly demonstrate the risk or benefit of these drugs,” Warner said. 

In addition, diminished ability to perform daily living activities – measured by an Eastern Cooperative Oncology Group (ECOG) Performance Status score of two or greater – was associated with a 3.89 times greater risk of 30-day mortality compared with greater physical ability (ECOG score of 0/1). Risk of death at 30 days increased nearly two-fold (1.83) with each decade of life. In addition, stable, non-progressing cancer was associated with a 1.79 times greater risk of death than no evidence of disease. Men had a 1.63 times greater risk of 30-day mortality than women. Lastly, former smokers had a 1.6 times greater risk of mortality than non-smokers. 

The researchers also reported on clinical outcomes. Half of patients included in this analysis (466) were hospitalized following onset of COVID-19 . Overall, 14% of all patients were admitted to the intensive care unit. Mechanical ventilation was required for 12% of all patients, and additional oxygen was required by 44% of patients.   

About the Study 
The CCC19 registry is open to site-level participation in the United States and Canada and is open to inclusion of anonymized individuals in Argentina, Canada, the European Union, the United States, and the United Kingdom.  

 As of April 16, 2020, half of patients in the registry were men; half were white, 16% were black, 16% were Hispanic, and 15% were other races and ethnicities. Breast cancer (21%) was the most common cancer, followed by prostate (16%), gastrointestinal (12%), lymphoma (11%), and thoracic (10%). In all, 43% of patients had active (measurable) cancer, 39% were on cancer treatment, and 45% were in remission.  

Next Steps 
Researchers are planning to conduct further analyses on this dataset and longer follow-up as the registry continues to accrue patients.  

Funding  
Funding was provided in part by the National Institutes of Health and the American Cancer Society. 

For Your Readers
Cancer.Net
Coronavirus and COVID-19: What People With Cancer Need to Know

View the disclosures for the Cancer Communications Committeehttps://www.asco.org/sites/new-www.asco.org/files/content-files/about-asco/pdf/2020-am-ccc-disclosures.pdf

View the disclosures for Dr. Burrishttps://coi.asco.org/share/UK4-3LNB/Howard%20Burris

Media Contact: Rachel Cagan
rachel.cagan@asco.org
mediateam@asco.org

For Patient Inquiries:
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ATTRIBUTION TO THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY ANNUAL MEETING IS REQUESTED IN ALL COVERAGE.

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Watch the 7-minute press briefing presentation

About ASCO: 

Founded in 1964, the American Society of Clinical Oncology, Inc. (ASCO®) is committed to making a world of difference in cancer care. As the world’s leading organization of its kind, ASCO represents nearly 45,000 oncology professionals who care for people living with cancer. Through research, education, and promotion of the highest-quality patient care, ASCO works to conquer cancer and create a world where cancer is prevented or cured, and every survivor is healthy. Conquer Cancer, the ASCO Foundation, supports the Society by funding groundbreaking research and education across cancer’s full continuum. Learn more at www.ASCO.org, explore patient education resources at www.Cancer.Net, and follow us on Facebook, Twitter, LinkedIn, Instagram, and YouTube.