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Daniel F. Hayes, MD, FACP, FASCO, is a Professor of Internal Medicine, the Stuart B. Padnos Professor in Breast Cancer, and the Clinical Director of the Breast Oncology Program at the University of Michigan Comprehensive Cancer Center. He is a breast cancer specialist.
An ASCO member since 1986, Dr. Hayes has served the Society in numerous volunteer capacities. In addition to serving as President-Elect, he is involved in several ASCO Expert Panels related to breast cancer, including the ASCO-College of American Pathologists Estrogen Receptor/Progesterone Receptor and the HER2 Testing Panels (Co-Chair), the Breast Cancer Consensus Panel, Use of Tumor Biomarkers in Advanced Breast Cancer and Early-Stage Breast Cancer Panels, and the Breast Cancer Guideline Advisory Group, among others. He served on the ASCO Board of Directors from 2011-2014, on the Conquer Cancer Foundation Grants Selection Committee, as Chair of the Scientific Program Committee, and on the Journal of Clinical Oncology Editorial Board. In 2007, he was presented with ASCO’s Gianni Bonadonna Breast Cancer Award and Lecture; in 2013, he was elected as a Fellow of ASCO (FASCO).
Dr. Hayes is past Chair of the Breast Cancer Intergroup of North America’s Correlative Sciences Committee and Chair of the Southwest Oncology Group’s Breast Cancer Translational Medicine Committee. He is a member of the Union for International Cancer Control (UICC) TNM Expert Advisory Panel on Breast Tumours and the Early Breast Cancer Clinical Trials Collaborative Group (the Oxford Overview) Executive Committee. He serves on the Susan G. Komen for the Cure Scientific Advisory Council as a Komen Scholar, in addition to several other past and current leadership roles.
Dr. Hayes completed his undergraduate degree and master’s degree in biochemistry at Indiana University and obtained his medical degree from Indiana University School of Medicine. He completed his internship and residency at Parkland Memorial Hospital/University of Texas Southwestern Medical School and a medical oncology fellowship at Harvard Medical School’s Dana-Farber Cancer Institute.
Disclosures: Stock and Other Ownership Interests with OncoImmune and InBiomotion; Honoria from Lilly; Research Funding with Janssen Research & Development (Inst.), AstraZeneca (Inst.), Puma Biotechnology (Inst.), Pfizer (Inst.), Lilly (Inst.), and Merrimack Pharmaceuticals/Parexel International Corporation (Inst.); Patents, Royalties and Other Intellectual Property with royalties from licensed technology to Janssen Diagnostics regarding circulating tumor cells; Travel, Accommodations, Expenses from Janssen Diagnostics.
Julie M. Vose, MD, MBA, FASCO, is the Neumann M. and Mildred E. Harris Professorial Chair and Chief of the Oncology/Hematology Division in the Department of Internal Medicine at the University of Nebraska Medical Center (UNMC). She is also the Associate Director of Clinical Research at the Fred and Pamela Buffett Cancer Center.
In addition to being ASCO President, Dr. Vose also serves on the Special Awards Selection, Nominating, and Scientific Program Committees. An ASCO member since 1991, Dr. Vose has served on the Board of Directors, Health Disparities Committee, Hematology-Oncology Task Force, Cancer.Net Advisory Panel and Editorial Board, and Journal of Clinical Oncology Editorial Board. She also served as Chair of the Cancer Education Committee and Publications Committee.
Dr. Vose was Co-Chair of the Lymphoma Steering Committee for the National Cancer Institute and has served on the U.S. Food and Drug Administration (FDA) Biologics Committee and the FDA Oncologic Drugs Advisory Committee (ODAC). She also served as Education Committee Chair for the American Society of Hematology and Education Committee Chair for the American Society of Bone Marrow Transplantation. In addition, Dr. Vose served as Journal Editor of Leukemia and Lymphoma, is on three additional editorial boards, and is a reviewer for 10 journals.
She received her undergraduate degree from South Dakota State University, her medical degree from the University of Nebraska Medical Center, and her MBA in health administration from the University of Colorado Business School. She completed her residency and was Chief Resident in internal medicine and her fellowship in Hematology/Oncology at the University of Nebraska Medical Center.
Disclosures: Consulting or Advisory Role with Bio Connections; Research Funding with Allos Therapeutics/Spectrum Pharmaceuticals (Inst.), Bristol-Myers Squibb (Inst.), Celgene (Inst.), Genentech (Inst.), GlaxoSmithKline (Inst.), Incyte (Inst.), Janssen Biotech (Inst.), Acerta Pharma (Inst.), Kite Pharma (Inst.), Seattle Genetics (Inst.).
Dr. Hudis is the CEO of the American Society of Clinical Oncology. Previously he served for nearly two decades as the Chief of the Breast Medicine Service and Attending Physician at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City where he was also a Professor of Medicine at the Weill Medical College of Cornell University. He was co-chair of the Breast Committee of the Alliance for Clinical Trials in Oncology (formerly Cancer and Leukemia Group), Chair of the Scientific Advisory Committee of the Breast Cancer Research Foundation, a former Associate Editor of the Journal of Clinical Oncology, and the President of ASCO during its 50th anniversary year, 2013-2014.
For almost 30 years Dr. Hudis worked to develop more effective treatment and prevention for breast cancer. His early work focused on translating the kinetic predictions of the Norton-Simon model into more effective dose-dense adjuvant chemotherapy programs. For the past decade he has studied the interplay of inflammation, obesity, and cancer and his group described low grade, chronic white adipose inflammation in most overweight and obese women. His group has made similar observations in other malignancies and risk groups and have used these insights to inform intervention studies and public policy initiatives at an international level.
Dr. Schilsky is the Senior Vice President and Chief Medical Officer (CMO) of ASCO. He assumed this newly created position with the Society in February of 2013. Formerly the Chief of Hematology/Oncology in the Department of Medicine and Deputy Director of the University of Chicago Comprehensive Cancer Center, he is a highly respected leader in the field of clinical oncology. He specializes in new drug development and treatment of gastrointestinal cancers. Dr. Schilsky is a Past President of ASCO, having served in the role during 2008-2009, and also a Past Chair of one of the National Cancer Institute’s Cooperative Groups, Cancer and Leukemia Group B (CALGB).
Dr. Schilsky’s impressive experience and many accomplishments in both clinical medicine and clinical research reflect his deep passion for cancer medicine. Having served in prior leadership positions within ASCO, Dr. Schilsky has an in-depth understanding of the current trends and issues affecting oncology clinical practice. He has spent the majority of his career at the University of Chicago where he joined the faculty in 1984, subsequently rising to the rank of Professor of Medicine and serving in many roles, including Associate Dean for Clinical Research in the Biological Sciences Division and Director of the University of Chicago Cancer Research Center.
From 1995 to 2010, Dr. Schilsky served as chair of the Cancer and Leukemia Group B, a national cooperative clinical research group funded by the National Cancer Institute (NCI). He has extensive experience working with both the NCI and the Food and Drug Administration (FDA) having served as a member and chair of the NCI Board of Scientific Advisors, as a member of the NCI Clinical and Translational Research Committee, and as a member and chair of the Oncologic Drugs Advisory Committee of the FDA. Dr. Schilsky has served on the editorial boards of many cancer journals, including the Journal of Clinical Oncology. Most recently, he served as an Associate Editor of the Journal of the National Cancer Institute and Senior Associate Editor of Molecular Oncology, among other journals.
Early in his career, he worked in the Clinical Pharmacology Branch of the Division of Cancer Treatment at the NCI and was an Assistant Professor in the Department of Internal Medicine, Division of Hematology and Oncology at the University of Missouri-Columbia School of Medicine. He was also the head of the hematology/medical oncology unit at the Harry S. Truman Veterans’ Administration Hospital in Columbia, Missouri.
Disclosures: Nothing to disclose
Harold J. Burstein, MD, PhD, is an Associate Professor of Medicine at Harvard Medical School, and a medical oncologist at Dana-Farber Cancer Institute and Brigham & Women's Hospital. Dr. Burstein attended Harvard College, and earned his MD at Harvard Medical School where he also earned a PhD in immunology. He additionally has a master's degree in history of science from Harvard. He trained in internal medicine at Massachusetts General Hospital and in medical oncology at Dana-Farber.
His clinical research interests include novel treatments for early- and advanced-stage breast cancer, and studies of quality of life and health behavior among women with breast cancer. Dr. Burstein has written widely on breast cancer in both traditional medical journals and on the web. Representative publications can be found in the New England Journal of Medicine, the Journal of Clinical Oncology, and other leading medical journals. He serves on international breast cancer committees including the NCCN Breast Cancer Panel, The St. Gallen Breast Cancer Panel, and the Alliance Breast Cancer Committee, and chairs the ASCO guidelines on endocrine therapy for breast cancer. Dr. Burstein is an Associate Editor for Cancer Education at the Journal of Clinical Oncology.
Disclosures: Nothing to disclose
Brian M. Alexander, MD, MPH, is the disease center leader for radiation oncology at the Center for Neuro-Oncology at the Dana-Farber Cancer Institute, as well as an assistant professor of radiation oncology at Harvard Medical School. He attended medical school at the University of Michigan, completed his internship at Saint Joseph Mercy Hospital in Ann Arbor, Michigan, and completed his residency in the Harvard Radiation Oncology Program. Dr. Alexander’s clinical and research interests include tumors of the central nervous system.
Disclosures: Consultant or Advisory Role with Abbvie, Precision Health Economics, and Schlesinger Associates.
Don S. Dizon, MD, FACP, is a medical oncologist specializing in the care of women's cancers. He did his training at the University of Rochester followed by residency at Yale New Haven Hospital. He did medical oncology fellowship at Memorial Sloan-Kettering Cancer Center and is a past recipient of a Conquer Cancer Foundation of ASCO Career Development Award. Following fellowship he was part of the faculty in the Developmental Therapeutics section and Gynecologic Oncology Disease Management Team until 2003. For the last nine years he has been the director of medical oncology at the Program in Women's Oncology at Women & Infants Hospital of Rhode Island and an Associate Professor in Obstetrics & Gynecology and Medicine at the Warren Alpert School of Medicine at Brown University where he was also the co-founder and co-director of the Center for Sexuality, Intimacy, and Fertility for women with cancer (CSIF) the first and only program of its kind in Rhode Island.
He joined UpToDate in 2011 as the Deputy Editor in Oncology and Palliative Care while maintaining an academic clinical practice. In July 2012, he transferred his clinical practice to MGH, where he founded and is director of the new Oncology Sexual Health Clinic at the MGH Cancer Center.
In addition to his clinical duties, he is an active columnist for ASCO Connection. In 2013 he received a Grand Award for Publishing Excellence (APEX) for Electronic Media for his ASCO Connection blog series.
Dr. Dizon is on Twitter @drdonsdizon.
Disclosures: Consulting or Advisory Role with UpToDate and Pfizer; and Research Funding with Aeterna Zentaris (Inst.).
Originally published in the 2008 ASCO Daily News
In her 30 years as an oncologist, Patricia A. Ganz, MD, has seen the evolution of cancer treatments progress from extreme radical surgical procedures to organ-sparing operations. She has witnessed the growth of the general understanding of the biology of cancer, an increasing trend of early diagnosis, and the identification of the molecular switches that control the initiation and promotion of cancer. She also remembers a time when people with cancer were low on the list of an oncologist’s priorities.
“In the late 1980s and early 1990s, it was not very popular to suggest that we include the patient’s voice in assessing the outcomes of treatment,” Dr. Ganz told ASCO Daily News. “Collecting quality-of-life data within clinical trials was viewed as burdensome.”
Quality-of-life and quality-of-care issues have come a long way in oncology, and Dr. Ganz has been a major force behind that progress. Her dedication to the prevention, detection, and treatment of cancer and to caring for the whole patient has contributed greatly to the expansion of oncology’s scope in recent years. For her achievements and professional leadership, ASCO is presenting Dr. Ganz with the 2008 ASCO/American Cancer Society Award. The award is designed to recognize individuals who have made significant contributions to the prevention and management of cancer. Dr. Ganz will accept the award and deliver her lecture, “Improving Outcomes of Cancer Survivors: Lessons Learned from the Treatment of Breast Cancer,” today from 11:30 AM–12:30 PM in the South Building, Room S404.
Before and After Cancer: Prevention and Survivorship
Dr. Ganz’s career in oncology began with a focus on patient issues. In 1973, she graduated with a medical degree from the University of California, Los Angeles (UCLA) School of Medicine and began her post-doctoral training in internal medicine and medical oncology at the UCLA Medical Center. Dr. Ganz notes that the study of cancer was in a transitional phase at that time. Adjuvant therapy for the disease was experimental but was demonstrating promise in prolonging survival. Except for Pap smears, there were no routine screening tests available for cancer. Most patients were diagnosed in the advanced stages of disease and, despite surgery and radiation therapy, recurrences were common. The hospice movement, focusing on pain and symptom management, was becoming increasingly influential. This movement was a part of Dr. Ganz’s first encounters with the incorporation of quality of life into the management of cancer.
“When I took my first faculty position after completing my fellowship training, I had the opportunity to start a palliative care unit for cancer patients. I decided that we should not wait until someone was in the last weeks of life to apply all of the supports of hospice, so we focused on physical rehabilitation, pain and symptom control, and psychosocial support from the time of diagnosis until death,” Dr. Ganz said. “Many patients in my practice had advanced disease and eventually succumbed, but some of my patients became long-term survivors, even then.”
Since that time, the field of oncology has shifted its focus and has acknowledged the significance of the experience that a patient has from the initial diagnosis through treatment and, increasingly, to survivorship. Researchers and clinicians not only seek to understand the biology of the disease and its treatments but also focus increasingly on the before and after of cancer: prevention and survivorship.
Current Research Regarding Quality-of-life Outcomes
Dr. Ganz has devoted her career to these aspects of oncology. Today, she is the Director of the Division of Cancer Prevention and Control Research of the Jonsson Comprehensive Cancer Center at UCLA, and leads a large research group that applies the scientific disciplines of public health to research on the prevention, detection, treatment, and supportive care of cancer. She is also Professor of Medicine at the David Geffen School of Medicine at UCLA and Professor of Health Services at the UCLA School of Public Health. Some of her recent research has investigated the significant effects that quality-of-life outcomes can have throughout the treatment of patients with cancer.
“After telling someone ‘you have cancer,’ they often shut down and don’t hear another word the physician says,” said Dr. Ganz, who currently Chairs the Behavioral and Health Outcomes Committee for the National Surgical Adjuvant Breast and Bowel Project (NSABP), an NCI-funded cooperative group. “The diagnosis can be extremely stressful even for those with the best coping skills.”
She noted that to the extent possible, the NSABP now routinely incorporates patient-reported outcomes in relevant treatment and prevention trials to enhance the interpretation of the biomedical findings.
“In leading the quality-of-life studies for the Breast Cancer Prevention Trial [BCPT] and the Study of Tamoxifen and Raloxifene [STAR], I was able to demonstrate the added value of patient-reported outcomes in the clinical trial setting,” Dr. Ganz said.
Stress can be compounded, she added, when patients must confront other issues surrounding their diagnosis, such as the lack of social support, poor or no health insurance, language barriers, or pre-existing medical or psychologic problems. As the patient moves through the treatment process, the issues they face often alter drastically.
Dr. Ganz’s research has explored the unique requirements and challenges in treating patients in all stages of cancer, including those who have survived it. For 20 years, she has led an active research program dedicated to investigating the effect of cancer treatment on the long-term health and well-being of breast cancer survivors. She was named a Susan G. Komen Breast Cancer Foundation Professor of Survivorship in 1999. In 2004, she served as Co-Chair of ASCO’s Survivorship Task Force. In 2006, she was awarded funding to lead UCLA’s Cancer Survivorship Center of Excellence as part of the LIVESTRONGTM Survivorship Center of Excellence Network. Today, after having served on the Institute of Medicine committee that prepared the 2005 report From Cancer Patient to Cancer Survivor: Lost in Transition, she continues to promote awareness in the medical community of the importance of improving the coordination of care for cancer survivors, including symptom management and supportive care.
“There will soon be 12 million cancer survivors and growing, and this is a target population for clinical trials as well as clinical care,” she said. “We need to learn from the outcomes of cancer survivors in order to appropriately modify our treatment strategies, as well as coordinate their post-treatment follow-up care.”
Ongoing Challenges for Cancer Survivors
Dr. Ganz emphasized that many cancer survivors require a unique kind of care from their oncologists. She noted that as a patient moves through treatment and into the survivorship stage, their needs shift as the chance for recurrence diminishes. Survivors may face ongoing symptoms or problems resulting from their initial treatments — pain, fatigue, menopausal symptoms — and be at risk for late effects, such as second cancers or organ dysfunction, as well as other chronic diseases.
“Oncologists do a good job with the cancer surveillance portion of care, but rarely address prevention, adequate management of symptoms (especially psychosocial needs), and health promotion. This is where survivorship care comes in,” she said. “Sharing the care of the patient with a primary care physician can ensure that symptom management, prevention, and health promotion are addressed.”
Dr. Ganz also has been an active advocate of the improvement of the cancer care that is delivered to all patients. She is the current Chair of ASCO’s Quality Cancer Care Committee and Co-Chair of the Cancer Quality Alliance, helping ASCO and other organizations develop and promote the measurement of quality care performance in clinical practice. In her research and professional activities, she is a leader in the promotion of the regular integration of evidence-based practices into everyday treatment.
“In oncology, we have far more evidence about what works and doesn’t work than many other aspects of clinical medicine. What we have learned from cancer clinical trials is not always put into practice,” said Dr. Ganz. “It is surprising how few physicians follow recommended treatment strategies, such as ASCO Guidelines.”
History of ASCO Service
An ASCO member since 1980, Dr. Ganz has volunteered in a variety of capacities for the Society, serving as a member of the Cancer Education Committee, the Scientific Program Committee, the Personnel Committee, the Cancer Prevention Committee, and the Strategic Planning Committee. From 2003 to 2006, she was a member of the Board of Directors, serving on the Executive Committee from 2005 to 2006. She also is an Editor for the Journal of Clinical Oncology and serves as a specialty editor for Clinical Cancer Advances. Recently, she also was the Chair of the Electronic Health Records Workgroup. For her lengthy record of service, the Society is presenting Dr. Ganz with a 2008 ASCO Statesman Award.
Dr. Ganz has been honored many times throughout her career with prestigious awards recognizing her leadership and dedication to oncology. In 1999, she was named an American Cancer Society Professor of Clinical Research. The Breast Cancer Research Foundation awarded her the Jill Rose Award for Breast Cancer Research in 2005 and she received the American Society of Breast Disease’s Pathfinder Award in 2006. In 2007, the American Cancer Society honored Dr. Ganz again with its Distinguished Service Award; also in 2007, Dr. Ganz was elected to membership in the Institute of Medicine.
After learning of her selection as the winner of the ASCO/American Cancer Society Award, she was “very honored to be nominated and selected by my colleagues.” She will focus her lecture on the lessons that she has learned from her work with breast cancer survivors.
“With the growing numbers of cancer survivors, members of ASCO need to be thinking about survivorship outcomes from the beginning of cancer treatment, including choice of treatments and the risks/benefits of late effects,” she said. “I am hopeful that we will see a continued decline in the incidence of cancer in the coming decades so that we less often have to say ‘I’m sorry, you have cancer.’”
Disclosures: Leadership with Intrinsic LifeSciences; Stock and Ownership Interests with Xenon Pharma (I), Intrinsic LifeSciences (I), Silarus Therapeutics (I), Merganser Biotech (I), Teva, Novartis, Merck, Johnson & Johnson, Pfizer, GlaxoSmithKline, and Abbot Laboratories; Consultant or Advisory Role with Keryx (I), Merganser Biotech (I), Silarus Therapeutics (I), and InformedDNA; Research Funding with Keryx (I); Patents, Royalties, Other Intellectual Property with related to iron metabolism and the anemia of chronic disease (I) and up-to-date royalties for section editor on survivorship; and Travel, Accommodations, Expenses with Intrinsic LifeSciences (I) and Keryx (I).
Smitha S. Krishnamurthi, MD, obtained her medical degree at University of Pennsylvania School of Medicine, Philadelphia, PA in 1993. She completed her residency in Internal Medicine at Hospital of the University of Pennsylvania, followed by a fellowship at Johns Hopkins University, in Medical Oncology. Dr. Krishnamurthi is a medical oncologist and an Associate Professor of Medicine at University Hospitals Case Medical Center and Case Western Reserve University.
Dr. Krishnamurthi is the Director of the Clinical Trials Office for the Case Comprehensive Cancer Center as well as Lower Gastrointestinal Cancers Disease Team Leader. Her research interests include gastrointestinal cancers and developmental therapeutics. In 2013 Dr. Krishnamurthi was named a Department of Medicine Master Clinician Educator. She has been recognized in Cleveland Magazine’s Best Doctors list for 10 consecutive years.
Disclosures: Research Funding from Nektar and Taiho Pharmaceutical.
Gary H. Lyman, MD, MPH, FACP, FRCP (Edin), FASCO, is Co-Director of the Hutchinson Institute for Cancer Outcomes Research, a Full Member of the Division of Public Health Sciences at the Fred Hutchinson Cancer Research Center, and a Professor of Medicine and Medical Oncology at the University of Washington.
In addition to serving on the ASCO Board of Directors, Dr. Lyman is a member of the Journal of Oncology Practice’s Editorial Board and Cancer Research Committee, as well as Chair of the Clinical Practice Guidelines Committee. He also sits on the Breast Cancer Consensus Panel, and is Co-Chair of the Breast Cancer Guideline Advisory and Survivorship Guideline Advisory Groups. An ASCO member since 1977, Dr. Lyman has served on the Journal of Clinical Oncology Editorial Board, the Cancer Education Committee, and as an Associate Editor of the Journal of Oncology Practice, among other activities.
Dr. Lyman has served as an advisor to the U.S. Food and Drug Administration’s Oncologic Drug Advisory Committee, and has been active in the Alliance for Clinical Trials in Oncology (formerly Cancer and Leukemia Group B), the Southwest Oncology Group, and the Eastern Cooperative Oncology Group. He has served on the Breast Cancer Screening and Diagnosis Panel and the Growth Factors Panel for the National Comprehensive Cancer Network, and as an editor for numerous academic journals.
Dr. Lyman received his medical degree from the State University of New York (Buffalo) and a Master of Public Health degree in Biostatistics from Harvard University School of Public Health. After completing a medical internship and residency at University of North Carolina, Chapel Hill, and a clinical medical oncology fellowship at Roswell Park Memorial Institute, he completed a postdoctoral fellowship at the Harvard University School of Public Health and the Dana-Farber Cancer Institute. He was Chief of Medicine at the Moffitt Cancer Center and Research Institute and Professor of Medicine at the University of South Florida and the University of Rochester before assuming his current positions at Duke University.
Gregory A. Masters, MD, FACP, FASCO, is an attending physician at the Helen F. Graham Cancer Center and serves as an Associate Professor at the Thomas Jefferson University Medical School. He earned his medical degree from Northwestern University, completed his residency at the University of Pennsylvania and finished his fellowship at the University of Chicago.
A lung cancer specialist, Dr. Masters also has interest in esophageal, gastrointestinal, head and neck cancers, thoracic oncology, and palliative care. He has served on the Thoracic Malignancies Steering Committee at the National Cancer Institute and works as a reviewer for several leading clinical oncology publications including Lancet, Journal of Clinical Oncology, Journal of Thoracic Oncology, Lung Cancer, Cancer, Clinical Lung Cancer, British Journal of Cancer and American Journal of Clinical Oncology.
Dr. Masters is the recipient of several awards and honors including the Fellow of the American Society for Clinical Oncology (FASCO), the ASCO Merit Award and the Christiana Care Health Services Physician Ambassador for Medical Oncology. He also serves as the Director of the Medical Oncology Fellowship for the Helen F. Graham Cancer Center and on the ASCO Cancer Communications Committee. As a published expert, he has traveled widely to speak on advancements in the treatment of Lung Cancer.
Disclosures: Nothing to disclose
Steven J. O'Day, MD is the Professor of Medical Oncology, Director of Immuno-Oncology, Director of Clinical Research of the Melanoma Medical Oncology Program at The John Wayne Cancer Institute at Providence St. John’s Health Center. He was most recently Director of the Los Angeles Skin Cancer Institute and Director of Clinical Research at The Beverly Hills Cancer Center. Prior to that, Dr. O’Day was Chief of Research and Director of the Melanoma Program at The Angeles Clinic and Research Institute in Los Angeles. He is a Clinical Associate Professor of Medicine at the University of Southern California (USC) Keck School of Medicine. He is a board certified medical oncologist.
Dr. O’Day’s medical training was at Johns Hopkins in Baltimore and the Dana Farber Cancer Institute in Boston. In 1994 Dr. O’Day came to Los Angeles to found the Medical Oncology Division of The John Wayne Cancer Institute in partnership with the world-class Surgical Oncology faculty and melanoma experts of The John Wayne Cancer Institute. More recently, he was a founding member of The Angeles Clinic and Research Institute in Santa Monica, California.
Dr. O’Day is recognized as one of the preeminent melanoma specialists in the world, and combines expert clinical care with teaching and leading clinical research. He lectures extensively, both nationally and internationally. He has been at the forefront of new drug development in melanoma over the last two decades. Dr. O’Day played a leadership role in the development of the breakthrough immune checkpoint inhibitor ipilimumab as well as the anti-PD1 antibodies pembrolizamab and nivolumab. In addition, he has participated in the development of the MAPK inhibitors vemurafinib, dabrafinib, and trametinib.
Dr. O’Day has been a principal investigator on over 100 clinical trials including several large, international phase III trials. He has published more than 200 manuscripts, abstracts, and reviews in prestigious journals such as The New England Journal of Medicine (NEJM), Journal of Clinical Oncology (JCO), Blood, Journal of American Medical Association (JAMA), Cancer, Lancet Oncology, and the Journal of the National Cancer Institute.
Dr. O’Day has served on the ASCO Education Committee for melanoma. In addition, he has served on the ASCO International Development and Education Award (IDEA) Working Group where he was a mentor for an IDEA grant recipient as well as an IDEA grant reviewer. Dr. O’Day recently completed a three-year term on the prestigious ASCO Cancer Communications Committee where he moderated ASCO press conferences, most notably the ASCO 2014 Immuno-Oncology Press Conference.
Disclosures: Honoraria from Bristol-Myers Squibb, Merck, Novartis, Amgen, and Incyte; Consulting or Advisory Role with Bristol-Myers Squibb, Merck, Novartis, and Amgen; Speakers’ Bureau with Bristol-Myers Squibb; Research Funding from Merck (Inst.), Amgen (Inst.), and Incyte (Inst.).
Olatoyosi Odenike, MD, is currently an Associate Professor of Hematology/Oncology in the Department of Medicine at the University of Chicago. She earned her medical degree from the University of Ibadan in Nigeria and completed her residency at the University of Illinois at Chicago, and fellowship in Hematology/Oncology at the University of Chicago.
An expert in the care of adults with leukemia, chronic myeloproliferative diseases and myelodysplastic syndromes, Dr. Odenike serves on the editorial board for the Blood Cancer Journal and Frontiers in Hematology-Oncology and as a reviewer for several medical journals. Additionally, she is a member of the Alliance Leukemia Committee, the International Working Group for Myelofibrosis Research and Treatment, the Molecular and Cellular Hematology NIH Study Section and currently serves on ASCO’s Grants Selection and Cancer Communications Committees.
Dr. Odenike has been listed in both Best Doctors of America and Marquis Who’s Who and is a recipient of the ASCO Career Development Award. The overall goal of her research is to improve treatment options for patients with myeloid neoplasms. She has published a number of original articles and has served as the principal investigator in several clinical trials. Additionally, Dr. Odenike frequently speaks around the country on advances in leukemia and myeloproliferative neoplasms.
Jyoti D. Patel, MD, is Associate Professor of Medicine, Division of Hematology/Oncology at Northwestern University Feinberg School of Medicine and leader of the Aerodigestive Malignancy Group of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. Her clinical and research interests include lung cancer chemotherapy and lung cancer in women.
Charles J Ryan, MD, is Professor of Clinical Medicine and Urology at the Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco (UCSF). He is the Leader of the Genitourinary Medical Oncology Program, overseeing the clinical research efforts of a group of genitourinary medical oncologists conducting clinical trials in prostate, kidney and bladder cancer. Within UCSF he is the Chair of the Genitourinary Oncology Clinical Research Site Committee and the Committee on Human Research (the UCSF IRB). Nationally, he serves as Co-Chair of the National Cancer Institute’s GU Steering Committee Prostate Cancer Task Force and is a member of the National Comprehensive Cancer Network (NCCN) Kidney/Testicular Cancer Guideline Panel, and the Leader of the Advanced Prostate Cancer Cadre in the Alliance for Clinical Trials in Oncology, an NCI sponsored cooperative group. Dr Ryan earned a bachelors degree from Marquette University and attended the University of Wisconsin Medical School. He trained in Internal Medicine at the University of Wisconsin Hospital and Clinics, where he also served as Chief Resident. He completed fellowship training in Medical Oncology at Memorial Sloan-Kettering Cancer Center and joined the faculty at UCSF in 2003.
His research focuses on novel therapy development in in castration resistant prostate cancer (CRPC) and has over 100 peer reviewed publications in this area. A major focus of his work has been the clinical development of CYP-17 inhibitors and related androgen receptor directed approaches to advanced disease.
Disclosures: Honoraria from Astellas Pharma and Janssen Oncology; Consulting or Advisory Role with Bayer and Millennium; Research Funding from BIND Biosciences, Karyopharm Therapeutics, and Novartis.
Lynn Mara Schuchter, MD, FASCO, is the University of Pennsylvania’s C. Willard Robinson Professor of Hematology/Oncology, Chief of the Hematology/Oncology Division and Program Leader for the Abramson Cancer Center’s National Cancer Institute approved and funded Melanoma Research Program. Her research has focused on the development of new treatments for patients with melanoma in studies that have focused on immunotherapy and targeted approaches. Dr. Schuchter has utilized her senior administrative, clinical, and investigative leadership strengths and experiences at the University of Pennsylvania to foster translational research. She has extensive experience in melanoma translational research, and thus serves as an important link between basic scientists and clinical investigators. She is a recognized expert in the field of melanoma and an experienced investigator in the development and conduct of melanoma clinical trials. She has been the principal investigator of numerous phase I, phase II, and phase III melanoma clinical trials. She is the immediate past chair of the scientific advisory committee and a member of the board of the Melanoma Research Foundation, a nationwide organization that is the largest advocate group for this disease. She is a recent past member of the American Society of Clinical Oncology (ASCO) Board of Directors, and current Chair of ASCO’s Cancer Research Committee. Dr. Schuchter has a strong commitment to and passion for mentorship and a long track record of success. She has a proven record of training physicians and scientists interested in both translational and clinical oncology research. She believes that careful mentoring is critical to the success of the next generation of cancer researchers which has been an essential component of her career. She serves as mentor for residents, fellows, and faculty and has particular interest in the mentorship of junior faculty.
Disclosures: Research Funding from GlaxoSmithKline (Inst.), Merck (Inst.), and Bristol-Myers Squibb (Inst.).
Andrew S. Epstein, MD, is an Assistant Attending Physician and Assistant Member at Memorial Sloan Kettering Cancer Center. He earned his medical degree at Loyola University of Chicago Stritch School of Medicine and completed his residency at New York’s Mount Sinai Hospital, where he was later a Palliative Medicine fellow. He completed medical oncology fellowship at Memorial Sloan Kettering Cancer Center, where he holds joint Department of Medicine service appointments in GI Medical Oncology and Palliative Medicine.
Clinically, Dr. Epstein cares primarily for patients with colorectal, pancreas, biliary, esophagogastric, and other gastrointestinal cancers.
His research focuses on improving the delivery of care to patients and their families by optimally integrating cancer care with palliative medicine, which is a rapidly growing medical specialty aimed at reducing distress and maximizing quality living for people with serious illnesses like cancer. For research work in patient–physician communication and education about cancer care planning, he received a Young Investigator Award from ASCO in 2010. For related research in cancer patient education and coping, he was granted a 2013 Career Development Award from the National Palliative Care Research Center (NPCRC). In collaboration with the Department of Psychiatry and Behavioral Sciences, he also teaches communication skills to medical oncology fellows at Memorial Sloan Kettering Cancer Center.
In addition, Dr. Epstein serves as a reviewer for various oncology publications including The Journal of Clinical Oncology, The Journal of Oncology Practice, JAMA Oncology, and Annals of Oncology.
Finally, Dr. Epstein serves as a member on the New York State Cancer Consortium Palliative Care Program Committee and the Steering Committee of What Matters: Caring Conversations About End of Life.
Disclosures: Other relationship with UpToDate.
John V. Heymach, MD, PhD, is the Chair of Thoracic/Head and Neck Medical Oncology and a Professor in the Departments of Thoracic Head and Neck Medical Oncology and Cancer Biology at The University of Texas MD Anderson Cancer Center. Dr. Heymach joined the faculty in 2005 as an Assistant Professor, with a joint appointment in Thoracic/Head and Neck Medical Oncology and Cancer Biology. He was promoted to Associate Professor in 2009 and Professor in 2013. He received his undergraduate degree from Harvard University and both his MD and PhD from Stanford University Medical School in California. He then completed his Internship and Residency at Brigham and Women’s Hospital and his fellowship in Medical Oncology at Dana Farber Hospital. During his fellowship, he worked in the laboratory of Dr. Judah Folkman with clinical mentorship under Dr. Bruce Johnson.
As a physician-scientist, his research focuses on investigating mechanisms of therapeutic resistance to targeted agents, understanding the regulation of angiogenesis in lung cancer, and the development of biomarkers for selecting patients most likely to benefit from targeted agents. He has led a number of Phase I/II clinical trials testing novel targeted therapies in NSCLC.
Dr. Heymach serves as a Project Co-Leader on the UT Lung Cancer SPORE and is the PI on three NCI R01 awards, a V Foundation Translational Research Award, a CPRIT Multi-Investigator Award Project, and is the site leader on a SU2C award. He also serves as leader of the Lung Cancer Program of the Cancer Center Support Grant and co-leads the MD Anderson Lung Cancer Moon Shot Program. He is a past recipient of the Damon Runyon Clinical Investigator Award, an ASCO Career Development Award, the Wilson Stone Award for Basic Science Research, and the Emil J. Frei Award for Translational Research. He was elected to the American Society for Clinical Investigation in 2013.
Disclosures: Stock and Other Ownership Interests from Cardinal Spine, LLC, and Bio-Tree; Consulting or Advisory Role from AstraZeneca, Abbvie, Boehringer Ingelheim, Bristol-Myers Squibb, Medivation, ARIAD, Synta, Oncomed, Novartis, Genetech and Calithera Biosciences; and Research Funding from AstraZeneca.
Merry-Jennifer Markham, MD, FACP, is an Associate Professor of Medicine at the University of Florida in the Division of Hematology and Oncology. She obtained her medical degree from the University of Miami Miller School of Medicine, in Miami, FL. She completed her residency in internal medicine followed by a fellowship in hematology and medical oncology at the University of Florida. She joined the faculty at the University of Florida in 2008. She serves as Program Leader for the UF Health Multidisciplinary Gynecologic Oncology Program. She is a clinical educator and investigator with a focus on gynecologic cancers and lymphomas. Her other clinical and research interests include quality improvement in cancer care and cancer survivorship.
Dr. Markham is on Twitter @DrMarkham.
Disclosures: Consulting or Advisory Role with Astex Pharmaceuticals; Research Funding (Inst.) with Astex Pharmaceuticals and Aduro Biotech (Inst.).
Erica L. Mayer, MD, MPH, is a Senior Physician and a breast cancer medical oncologist at the Susan F. Smith Center for Women’s Cancers/Dana-Farber Cancer Institute, as well as an Assistant Professor in Medicine at Harvard Medical School.
Dr. Mayer received her medical degree from Harvard Medical School in 2000. She completed a residency in Internal Medicine at Brigham and Women's Hospital, a chief residency in Internal Medicine at Faulkner Hospital, and a fellowship in Hematology/Oncology at Dana-Farber Cancer Institute/Partners CancerCare. She obtained a Master's in Public Health from the Harvard School of Public Health.
Dr. Mayer’s research focuses on the role of novel therapies in the treatment of advanced breast cancer. She has been published in numerous peer-reviewed publications including Nature, Journal of Biological Chemistry, Clinical Breast Cancer, Journal of Clinical Oncology, American Journal of Surgery, Annals of Oncology, and Clinical Cancer Research. She is the Associate Director of the Dana-Farber Partners CancerCare Hematology/Oncology Fellowship Program, and Co-Chair of the Dana-Farber Cancer Institute Clinical Faculty Council. Dr. Mayer is an active member of ASCO, ALLIANCE, as well as the Translational Breast Cancer Research Consortium. She is a graduate of the ASCO Leadership Development Program, has chaired the ASCO Cancer Education Committee Breast Track, and is a member of the ASCO Cancer Communications Committee.
Disclosures: Research Funding with Myriad Genetics and Pfizer.
Sumanta (Monty) Kumar Pal, MD, is an internationally recognized leader in the area of genitourinary cancers, including kidney, bladder, and prostate cancer. He is the Co-director of City of Hope's Kidney Cancer Program and is the head of the kidney and bladder cancer disease team at the institution.
Dr. Pal entered college at the age of 13 and began medical school at University of California, Los Angeles at the age of 17. After completing his residency training at University of California, Los Angeles, Dr. Pal completed a fellowship program in medical oncology at City of Hope's comprehensive cancer center where he remains on faculty since 2009.
Over that span of time, he has published more than 150 peer-reviewed articles that have been featured in prominent journals including The Journal of Clinical Oncology, Lancet Oncology, Cancer Cell, and European Urology.
Dr. Pal holds patents for new drugs currently under development in prostate cancer and also maintains one of the largest portfolios of clinical trials for kidney and bladder cancer research on the west coast. He developed an integrated program that focuses heavily on collaborations with basic science researchers at Beckman Research Institute of City of Hope and urologists in the Department of Surgery. Ultimately, Dr. Pal’s goal is to stimulate collaborative research across multiple departments in order to discover novel therapeutic approaches for our currently incurable diseases. He has also worked to push the boundaries of personalized medicine in genitourinary cancers, with several seminal publications in rare genitourinary cancers that describe unique therapeutic targets.
Dr. Pal sits on the Editorial Board for clinical genitourinary cancer and is a reviewer for multiple journals including The Journal of Clinical Oncology, The Journal of Urology, European Urology, and many others. Dr. Pal has received grants from the National Institute of Health, the Comprehensive Cancer Network, the Southwest Oncology Group, and multiple other leading entities in support of his formidable research.
Disclosures: Honoraria with Novartis, Medivation, Astellas Pharma; Consulting or Advisory Role with Pfizer, Novartis, Aveo, Myriad Pharmaceuticals, Genentech, Exelixis, Bristol-Myers Squibb, and Astellas Pharma.
Michael S. Sabel, MD, FACS, is the William W. Coon Collegiate Professor of Surgical Oncology in the Department of Surgery and the Chief of the Division of Surgical Oncology at the University of Michigan. He completed his undergraduate training at Pennsylvania State University and obtained his medical degree from Temple University School of Medicine in Philadelphia. His general surgery residency was performed at Rush-Presbyterian-St. Luke’s Medical Center in Chicago. Dr. Sabel completed an NIH-T32 research fellowship in tumor immunology and a surgical oncology fellowship at Roswell Park Cancer Institute in Buffalo, NY. Dr. Sabel joined the University of Michigan faculty in 2001. He has been listed in Best Doctors in America in Surgical Oncology every year since 2007 and has named as one of the U.S. News and World Report Top Doctors in Surgery since 2011.
Dr. Sabel’s clinical interests are in the area of surgical oncology, with special expertise in breast cancer and melanoma. Dr. Sabel’s research interests focus on the immune response to cancer cell death, particularly after cryoablation (freezing) of cancer, and he is an internationally recognized expert in the field of cryo-immunology. Dr. Sabel’s lab is also focused on the identification of prognostic and predictive markers in oncology, using both serum proteomic and tissue microarray approaches, to help guide surgical and adjuvant therapy.
In addition to his clinical and basic science interests, Dr. Sabel has strong clinical interests in the use of mobile technologies to improve patient-physician communication and improve outcomes. He is the creator of three present apps; UMSkinCheck for early melanoma detection, and BreastCancerAlly and MelanomaAlly, mobile patient navigator apps for patients requiring multidisciplinary cancer care.
Disclosures: Consulting or Advisory Role from Merck; and Patents, Royalties, Other Intellectual Property from Breast Cancer Ally and Melanoma Ally mobile technologies.
Lidia Schapira, MD, is a medical oncologist at the Gillette Center for Breast Oncology at the Massachusetts General Hospital Cancer Center and Assistant Professor of Medicine at Harvard Medical School. She graduated from Dartmouth Medical School and trained at the Beth Israel Hospital and the Brigham and Women's Hospital. Dr. Schapira specializes in the care of women with breast cancer.
Dr. Schapira's research has focused on improving communication between patients and physicians and how best to meet the needs of patients and their families along the continuum of disease. She has developed innovative curriculum for postgraduate medical education and led workshops designed to improve the knowledge and skill set of clinicians. Dr. Schapira has also studied the barriers to communication and participation in cancer clinical trials. She has worked with professional societies and advocacy groups to improve awareness and bridge communication gaps that deter patients from participating in cancer clinical trials. In addition to research and clinical practice, Dr. Schapira is an active member of the Academy at Harvard Medical School and the Empathy and Relational Science Program at the Massachusetts General Hospital in Boston.
Dr. Schapira served on the Board of Directors of the American Psychosocial Oncology Society. In 2010 she received a "Statesman Award" from ASCO for her years of dedicated service to this professional society.
Disclosures: Consulting or Advisory Role with bioTheranostics.