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Sub-category:
Proteomics/Immunohistochemistry
Category:
All
Meeting:
2008 Molecular Markers
Session Type and Session Title:
General Poster Session B
Abstract No:
86
Author(s):
M. Mokri, M. Guity, S. Shariat Torbaghan, M. Bagherzadeh, M. Atri
Abstract:
Background: The Nottingham score (NS), a histological grading system for invasive breast carcinoma include by; Tubule formation, Nuclear pleomorphism and Mitotic rate as criteria and each are assigned 1,2 or 3 points and the scores are added for a combined histological score. Tumors are graded based on the combined score into grade I (3-5, well differentiated), grade II (6-7, moderately differentiated) and grade III (8-9 poorly differentiated). Hormones receptors (ER and PR) and Her-2/neu gene or its protein are now routinely evaluated in all breast cancer cases. Her- 2/neu overexpression is associated with features of a poor prognosis like high tumor grade and S- phase fraction, nodal metastasis and estrogen (ER) and progesterone receptor (PR) negativity. Its overexpression produces ligand independent down regulation of ER. The reduced hormone receptor expression might be one of the mechanism by which HER2/neu positive tumors show a decreased response to hormonal agents and decreased DFS. Methods: The data on all women reviewed pathology reports invasive ductal carcinoma of breast cancer in our community hospital were retrospectively analyzed. The final analysis had 420 patients. The receptor status and NS were tabulated. We divided all the patients into Her-2/neupositive 185 and negative 235 and later subdivided into hormone receptor (both ER and PR) negative or positive (ER or PR). Results: Her2/neu neg, ER or PR (+ ) in NS 3-5, NS 6-7 and NS 8-9 arrangement by: 3 (5.5%), 11 (40.3%) and 10 (34.4%). Her2/neu neg, ER and PR (- )in NS 3-5, NS 6-7 and NS 8-9 arrangement by: 7 (4.9%), 17 (11.9%) and 30 (21%). Her2/neu pos, ER or PR (+) in NS 3-5, NS 6-7 and NS 8-9 arrangement by: 4 (8.2%), 6 (26.9%) and 9 (47.6%). Her2/neupos, ER and PR (-) in NS 3-5, NS 6-7 and NS 8-9 arrangement by: 5 (3.1%), 15 (9.4%) and 37 (23.1%). Conclusions: In this study itis observed that ER or PR positivity shows a trend towards lower NS. The patents with triple receptor negative status had higher NS. This suggests a correlation between NS, receptor status and DFS.
Abstract Disclosures
Abstracts that were granted an exception in accordance with ASCO's Conflict of Interest Policy
and are designated with a caret symbol (^) here and in the print version.
 Associated Presentation(s):
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Abstracts by M. Mokri:
Presentations by M. Mokri:
Educational Book Manuscripts by M. Mokri:
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