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Sub-category:
Prevention, Screening, and Diagnosis
Category:
Colon and Rectum
Meeting:
2005 Gastrointestinal Cancers Symposium
Session Type and Session Title:
Cancers of the Colon and Rectum - General Poster Session
Abstract No:
170
Author(s):
R. E. Carroll, D. M. Moxon, R. Kenney, R. Ewing, A. Arozullah
Abstract:
Background: In clinical studies, diminished folate availability appears to increase the risk of colorectal neoplasms. Additionally, alcohol and tobacco use are associated with an increased risk of colon cancer but the early pathologic events by which these agents promote neoplastic transformation, are not well understood. Aberrant crypt foci (ACF) are potential precursors of adenoma and cancer, and can be visualized by magnification endoscopy. We hypothesized that folate depletion is linked to ACF formation and therefore studied the association between tissue folate, dietary habits, and ACF number in patients undergoing screening colonoscopy. Methods: Eighty three subjects, undergoing screening colonoscopy at an urban VA and university hospital, completed a questionnaire concerning alcohol, NSAID and tobacco use. Folate intake was calculated from food frequency questionnaires. Rectal ACF were scored using magnification chromoendoscopy (mag 35X) by methylene blue staining. Folate concentrations in rectal biopsies were determined by microtiter bio-assay. Results: ACF number was significantly increased in subjects with advanced neoplasia. (adenomas >1cm ). ACF number increased exponentially with age and with increasing tobacco intake. Reduced colonic folate was associated with elevated homocysteine levels and lower dietary folate intake but did not correlate with ACF number. Conclusions: Increasing age and tobacco use were independently linked to the presence of colonic ACF in this predominately African-American population. Folate, alcohol, and ASA use did not influence the prevalence of these lesions. The natural history of these lesions over time is important to define as they could potentially risk stratify patients as to the optimal interval for performance of screening colonsocpy in an aging population .
 Associated Presentation(s):
Other Abstracts in this Sub-Category:
Abstracts by R. E. Carroll:
Presentations by R. E. Carroll:
Educational Book Manuscripts by R. E. Carroll:
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