|
Sub-category:
Lymphoma
Category:
Adult Leukemia, Lymphoma and Transplantation
Meeting:
2004 ASCO Annual Meeting
Abstract No:
6716
Citation:
Journal of Clinical Oncology, 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 22, No 14S (July 15 Supplement), 2004: 6716
Author(s):
S.-H. Ji, S.-H. Lee, J. H. Kim, K. Kim, W. S. Kim, J. O. Park, C. W. Jung, W. K. Kang, M. H. Lee, K. Park; Samsung Medical Center, Sungkyunkwan University, Seoul, Republic of Korea
Abstract:
Background: NK/T-cell lymphoma is a specific type of T-cell lymphoma which is prevalent in Eastern Asia and known to have poor prognosis. With the hope of better treatment outcome, we developed new induction regimen using dose-escalated doxorubicin and cyclophosphamide, and higher dose-intensity. Methods: Newly diagnosed, modified Ann-Arbor stage I and II, NK-T cell lymphoma patients were enrolled. We planned to treat them with 2 cycles of dose-intensive CHOP (DI-CHOP), followed by radiation (total 40 Gy with 20 fractions) and 4 cycles of conventional CHOP. DI-CHOP consisted of cyclophosphamide (1250 mg/m2, day 1), doxorubicin (75 mg/m2, day 1), vincristine (1.4 mg/m2, day 1) and prednisolone (100 mg/day for 5 days) with growth factor support (G-CSF 150 ug/day for 10 days). The second cycle of DI-CHOP was started as soon as possible when ANC more than 1500/uL and platelet count more than 75,000/uL no less than 14 days since day 1 of the first cycle. Results: From March 2000 to May 2003, consecutive 12 patients were accrued. Ten patients (83%) completed 2 cycles of DI-CHOP and radiation. Seven patients (58%) completed all planned treatment. The interval between the first and second cycle of DI-CHOP was 14 to 23 days (median, 14 days). Eight patients (67%) achieved complete remissions and three patients (25%) partial remissions. With median follow-up duration of 14.9 months, four patients (33%) experienced relapses and no patient died in relation to disease progression. Eight patients (67%) experienced grade 4 neutropenia and four patients (33%) febrile neutropenia during DI-CHOP. One patient experienced septic shock leading to treatment-related mortality. Conclusions: Dose-intensive induction CHOP preceding radiation was a feasible approach against localized NK/T-cell lymphoma, but short follow-up and small number of accrual limit us to conclude this approach is more effective than conventional CHOP induction.
 Associated Presentation(s):
Other Abstracts in this Sub-Category:
Abstracts by S.-H. Ji:
Presentations by S.-H. Ji:
Educational Book Manuscripts by S.-H. Ji:
|
